Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Several of the novel?alterations induced cancerous phenotypes in cell lines and mouse xenograft models?and demonstrated sensitivity to tyrosine kinase inhibitors. Stratifying ALL patients may improve clinical outcomes through the use of therapies targeted to the specific genetic alteration.
7x彩票网邀请码Researchers describe emerging approaches that aim to determine which altered genes are actually contributing to cancer, as well as their potential as therapeutic targets.
Investigators screemed a library of kinases that lead to activation of the MAPK pathway and identified PAK1.
7x彩票网邀请码The study identified a recurrent somatic novel gene fusion between TBL1XR1 and TP63 by analyzing transcriptome data from 96 DLBCL cases.
Glioblastoma is both the most common and lethal primary malignant brain tumor.
7x彩票网邀请码The fusion of empirical science with large-scale computing platforms has allowed rapid advances in our ability to model physiological and pathophysiological processes in silico.
In the largest pediatric cancer genome sequencing effort reported to date, TARGET ALL researchers sequenced 120 candidate genes in 187 high-risk childhood B-precursor acute lymphoblastic leukemias (HR B-ALL).
7x彩票网邀请码Morin et al. uncovered a novel role for chromatin modification in driving the progression of two non-Hodgkin lymphomas (NHLs), follicular lymphoma and diffuse large B-cell lymphoma.