Publications

Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.

* denotes publications from the CTD2 initiative that are results of intra-Network collaborations

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TARGET
August 14, 2012
Cancer Cell

Several of the novel?alterations induced cancerous phenotypes in cell lines and mouse xenograft models?and demonstrated sensitivity to tyrosine kinase inhibitors. Stratifying ALL patients may improve clinical outcomes through the use of therapies targeted to the specific genetic alteration.

CTD2
August 10, 2012

7x彩票网邀请码Researchers describe emerging approaches that aim to determine which altered genes are actually contributing to cancer, as well as their potential as therapeutic targets.

CTD2
July 19, 2012
Oncogene

Investigators screemed a library of kinases that lead to activation of the MAPK pathway and identified PAK1.

CGCI
May 24, 2012
Blood

7x彩票网邀请码The study identified a recurrent somatic novel gene fusion between TBL1XR1 and TP63 by analyzing transcriptome data from 96 DLBCL cases.

CTD2
April 15, 2012
Genes and Development

Glioblastoma is both the most common and lethal primary malignant brain tumor.

CTD2
October 05, 2011
Sci Trans Med.

7x彩票网邀请码The fusion of empirical science with large-scale computing platforms has allowed rapid advances in our ability to model physiological and pathophysiological processes in silico.

TARGET
September 15, 2011
Blood

In the largest pediatric cancer genome sequencing effort reported to date, TARGET ALL researchers sequenced 120 candidate genes in 187 high-risk childhood B-precursor acute lymphoblastic leukemias (HR B-ALL).

CGCI
July 27, 2011
Nature

7x彩票网邀请码Morin et al. uncovered a novel role for chromatin modification in driving the progression of two non-Hodgkin lymphomas (NHLs), follicular lymphoma and diffuse large B-cell lymphoma.

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