CTD2: Cancer Target Discovery and Development

The Cancer Target Discovery and Development (CTD27x彩票网邀请码) Network, a functional genomics initiative, bridges the gap between cancer genomics and biology. The Network aims to understand how tumor heterogeneity leads to drug resistance in order to develop optimal combinations of chemotherapy or small molecules in combination with immunotherapy.?

Banner for CTD squared program. Links to CTD squared program page
Last updated: January 03, 2019

News & Publications

previousnext
Copyright ? 2020 Elsevier B.V.
CTD2
March 03, 2020

7x彩票网邀请码The immune composition of the tumor microenvironment influences response and resistance to immunotherapies. While numerous studies have identified somatic correlates of immune infiltration, germline features that associate with immune infiltrates in cancers remain incompletely characterized. We...

Initiation of Ferroptosis by Inhibition of Xc-system or GPX4 Activity
CTD2
March 01, 2020

Ferroptosis is widely involved in degenerative diseases in various tissues including kidney, liver and brain, and is a targetable vulnerability in multiple primary and therapy-resistant cancers. Accumulation of phospholipid hydroperoxides in cellular membranes is the hallmark and rate-limiting...

Schematic representation of microfluidics based scRNA-seq workflow
CTD2
February 14, 2020

Purpose:?7x彩票网邀请码The tumor microenvironment (TME) consists of a heterogenous cellular milieu that can influence cancer cell behavior. Its characteristics havean impact on treatments such as immunotherapy. These features can be revealed with single-cell RNA sequencing (scRNA-seq). We...

Graphical abstract from McGrail et al., 2020.
CTD2
February 14, 2020

Deficient DNA mismatch repair (dMMR) induces a hypermutator phenotype that can lead to tumorigenesis; however, the functional impact of the high mutation burden resulting from this phenotype remains poorly explored. Here, we demonstrate that dMMR-induced destabilizing mutations lead to proteome...

Glioblastoma macro
CTD2
February 14, 2020

Members of the scientific and clinical neuro-oncology community met in April 2019 to discuss the current challenges and opportunities associated with translating basic science discoveries in glioblastoma to improved survival for patients. A summary of key points of these discussions is presented...

O
O
O
O
O