7x彩票网邀请码Computational analysis of two large-scale independent CRISPR-Cas9 viability screens performed at the Broad and Sanger Institutes indicate reproducible findings in identifying gene dependencies.
7x彩票网邀请码Human pluripotent stem cells-derived natural killer cells have improved antibody-dependent cellular cytotoxicity and could be used to treat refractory malignancies.
Researchers identify that mechanistic target of rapamycin (mTOR) kinase inhibitor, PP242 induces cell death in glioblastoma cells by off-target inhibition of both protein kinase C alpha and Janus kinase 2 (JAK2).
7x彩票网邀请码Scientists compared performance of RNA-Seq processing pipelines for the expression quantification of long non-coding RNAs (lncRNAs) in cancer samples. This study indicates integrating pseudoalignment methods with transcriptome annotation is a recommended strategy for RNA-Seq analysis of lncRNAs.
CTD2 scientists at DFCI performed genome-scale open reading frame screens to identify mechanisms of resistance to androgen deprivation therapy. This study shows that transcription factor, CREB5, is overexpressed and mediates resistance to androgen receptor antagonists in prostate cancer.
7x彩票网邀请码Glioblastoma cells develop resistance to blockade the transcription factor?STAT3. UCSF studies show?that autocrine feedback loop among STAT3, EGFR?and NF-KB mediates?primary resistance?and suggest?combinatorial therapy?to treat?EGFR-amplified glioblastomas.
CTD2?scientists at Stanford University performed integrative analysis of early-stage breast cancer patient and cell line data to study the role of chromatin regulatory genes (CRG). These studies indicate, CRGs?that promote DNA accessibility are associated with anthracycline sensitivity.
7x彩票网邀请码Neuroblastoma cells treated with RXDX-105, a small-molecule inhibitor of multiple kinases decreased cell viability and proliferation in vitro and in vivo.
Emory University CTD27x彩票网邀请码 scientists showed that NSD3S plays a critical role in the regulation of MYC function through inhibition of FBXW7-mediated degradation of MYC. This interaction drives cancer cell survival and could be a potential therapeutic target in MYC-driven tumors.
7x彩票网邀请码Epigenomic analysis of methylation data using Onco-GPS computational approach identify subtypes of myelodysplastic syndromes. The subtypes had distinct patterns of genetic lesions, regulatory region methylation, and prognostic response.